Connective Issue #27

MIB News
Connective Issue #27

Volume 27 | November 6, 2024

Companions for a Cause

Did you know that osteosarcoma is one of the more common cancers in dogs, with an estimated 10x incident rate compared to humans? For November Pet Cancer Awareness Month, we spotlight the Flint Animal Cancer Center at Colorado State University, home of the One Cure founding principle that treatment breakthroughs come through collaborations between scientists and doctors who are working with pets and people.

Our furry companions not only bring us joy and comfort, but they are truly our partners in advancing treatments and improving outcomes for all osteosarcoma patients.  

Inspired by our companions for a cause, we invite you to Make It Pawsitively Better with us this month:

- OutBark Osteoarcoma with us! Purchase a fashionable bandana for your dog and enter your dog into a paw-some photo contest. All proceeds benefit osteosarcoma patient programs and research.

- Order stunning holiday cards with original artwork by OsteoWarriors. Send one to your dog!

- Help us send holiday cheer to OsteoWarriors - shop a curated list of gifts for our Warrior Mail holiday shipment.  

- Join the CURE-OS working group, and collaborate with colleagues in the study of canine and human osteosarcoma heterogeneity by single cell technologies.

Thank you for being part of our pack.

With hope and gratitude,

Ann

Save The Date

OUR COMMUNITY

OutBarking for Pet Cancer Awareness Month

With a $16 donation, your dog can proudly wear a gold MIB dog bandana, helping to raise awareness for osteosarcoma, which has an estimated 10x higher incidence in dogs than in humans. Enter our "Who Wore It Best" photo competition by taking a picture of your dog in the bandana and creating a fundraising page to share their story. Encourage your friends and family to vote for your furry friend—each vote is a $5 donation that Makes It Better for kids and pups facing osteosarcoma. Together, we’re building hope, one wag and one vote at a time. Share your photos on your fundraiser page, and be sure to tag us with #OutBarking!

Get Your Bandana Here

Start OutBarking Today!

Spread Holiday Cheer with MIB Greeting Cards!

Showcase the heartfelt talent of six beloved MIB OsteoWarriors with each stunning, original artwork. Every box includes 12 beautifully designed cards and 13 envelopes, perfect for sharing joy this season. Only $24 with FREE Shipping!

Order Your Holiday Cards

Spotlight on the CSU Flint Animal Cancer Center

November is Pet Cancer Awareness Month, a time to reflect on the challenges faced by our furry companions battling this disease and how they help make it better for human osteosarcoma patients. The incidence of osteosarcoma in dogs is estimated to be ten times higher than in humans, underscoring the importance of comparative oncology, where insights gained from veterinary cases can significantly advance our understanding and treatment of cancer in human patients. This month we spotlight the Flint Animal Cancer Center at Colorado State University, a leading institution dedicated to the study and treatment of cancer in animals. Their innovative research and clinical practices not only aim to improve outcomes for pets but also hold potential to unlock breakthroughs that can benefit human patients. Doug Thamm, VMD and Dan Regan, DVM, PhD lead the clinical and research programs respectively and they share with us the philosophy behind the One Cure goal to improve the prevention, diagnosis, and treatment of cancer in pets and then use that research and knowledge to also benefit people with cancer.

Learn More About the Flint Animal Cancer Center

Career Connections

- Program Head, Sarcoma - Fred Hutchinson Cancer Center: Clinical Research Division

- Medical Oncology, Sarcoma Oncology Clinical Faculty - Cedars Sinai

- Medical Oncologist, Sarcoma - Mayo Clinic

- Asst or Assoc Professor, Sarcoma Oncology - Fred Hutchinson Cancer Center

- Orthopaedic Oncologist - Ochsner Health

- Clinical Faculty, Solid Tumor Focus - Riley Children's Health

- Associate Professor or Professor, Tenure Track, Pediatric Sarcoma Research - UPenn

- Associate or Full Professor (Program Head, Sarcoma Program) - UW

- Postdoctoral Fellow, Sarcoma Medical Oncology - MDACC

- Assistant Professor, Sarcoma - OHSU

- Sarcoma Oncologist - Georgetown Cancer Institute

- Pediatric Oncology Solid Tumor Clinician Educator - Stanford

If you have a job posting and you would like it included here, please email christina@mibagents.org.

EDUCATION

OsteoBites Webinar Series

Nov 7 | Arianexys Aquino-López, MD, PhD
Repurposing Virus Specific T cells as Immune Therapy for Osteosarcoma
Nov 21 | osTEAo AYA Podcast
Hospital Holidays
Dec 5 | Chris Richards, PhD
Macrophage Engineered Vesicles to Treat Pediatric Osteosarcoma
Dec 12 | Chelsey Burke, MD
Understanding Tumor Evolution in Osteosarcoma

Watch Past Episodes and See the Upcoming Schedule

Osteosarcoma in the News

- VCP enhances autophagy-related osteosarcoma progression by recruiting USP2 to inhibit ubiquitination and degradation of FASN

- Inhibition of mitochondrial OMA1 ameliorates osteosarcoma tumorigenesis

- Development and validation of a novel endoplasmic reticulum stress-related lncRNAs signature in osteosarcoma

- 3D Tumor-Engineered Model Replicating the Osteosarcoma Stem Cell Niche and In Vivo Tumor Complexity

- Novel platinum nanoclusters (Pt NCs) induce mitochondrial apoptosis and damaging autophagy for the treatment of osteosarcoma—from the perspective of P53 mutation status in different cell lines

- Lenvatinib Plus Ifosfamide and Etoposide in Children and Young Adults With Relapsed OsteosarcomaA Phase 2 Randomized Clinical Trial

- Phase II Trial of Gemcitabine and nab-Paclitaxel for Recurrent Osteosarcoma with Serial Monitoring Using Liquid Biopsy: A Report from the National Pediatric Cancer Foundation

- Tumor-targeted glutathione oxidation catalysis with ruthenium nanoreactors against hypoxic osteosarcoma

PROGRAMS

Send Holiday Cheer to OsteoWarriors

Send Holiday Cheer to OsteoWarriors

Seeking Secret Agents for an Important Mission

RESEARCH

Learn about Canine Osteosarcoma Trials

Join the Osteosarcoma scRNAseq Working Group

CURE-OS (Collaborative Understanding of the Range and Evolution of Osteosarcoma Single-cells) is an international working group dedicated to the study of heterogeneity in osteosarcoma by single cell technologies. By sharing knowledge and establishing standards for the collection, analysis, and dissemination of single cell data in osteosarcoma, the group's goal is to advance osteosarcoma single cell research toward improving the care of OS patients by:

- Disseminating knowledge and facilitate collaborative research through expert talks.

- Developing an international consensus on key goals and standards for osteosarcoma single cell research to support a unified osteosarcoma atlas in support of future studies.

- Creating a shared repository for osteosarcoma single cell research data and methodologies.

The group is open to anyone interested in the study of osteosarcoma heterogeneity by single cell technologies.

Join the CURE-OS Working Group

Submit an Abstract by January 10th, 2025

Read the Abstract Guidelines

Submit an Abstract

If you have a trial that is currently enrolling osteosarcoma patients, please email christina@mibagents.org.

All MIB Agents programs are free of charge, thanks to donors like you who Make it Better. Please consider a donation to support osteosarcoma patient programs, education, and research. 
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