Volume 22 | June 5, 2024

We Meet at FACTOR and Wherever You Are At

June is one of our favorite months because we get to gather with our community in person at FACTOR!

If you are planning to attend, we have some tips to help you prepare:

- Conference check-in opens at 2 pm on Thursday, June 20th followed by the Welcome Reception and our annual Docs vs. Warriors fun and games at 5 pm.

- View the agenda to preview the Scientific Panel content and Wellness offerings

- Watch our layperson Guide to the FACTOR 2024 Scientific Panels to get the most out of the General Session

- Read about Maeve & Michelle, our FACTOR Warrior HQ leads, to learn what they have in store for our Warriors and siblings this year

- Party attire is encouraged for our Enchanted Forest Prom after Friday dinner. Bring your dancing shoes!

And if you are unable to join us in Cleveland this year, you can still be part of FACTOR from afar!

- Contribute to the best ever Warrior HQ experience and shop the Warrior HQ Amazon wishlist for games, crafts, and fun and FACTOR.

- Order a Luminaria in honor of an OsteoWarrior or OsteoAngel, which will light our path to Friday dinner.

- OutBid Osteosarcoma with us and shop the virtual auction June 19th-June 22nd.

While we look forward to gathering in person, we are all part of a greater community bonded by a common goal that supersedes geographic boundaries, languages, and time zones. Please check out our updates this month on our education and patient programs like Warrior Mail, OsteoBites, TURBO, and Clinical Trial Resources which connect us and make resources available to our constituents wherever they are at.

With hope,

Ann

Save The Date

^{OUR COMMUNITY}‍

2 Weeks to FACTOR

We are so excited to gather with our community in 2 weeks at FACTOR! If you haven't registered yet, there is still some limited availability. The Hotel Cleveland is sold out for rooms, but you can take advantage of a discounted conference rate at the nearby Westin Cleveland Downtown. Already registered for FACTOR? Get ready!

Watch the Guide to the FACTOR 2024 Scientific Panels where Dr. Matteo Trucco breaks down the scientific sessions for our layperson audience.

Pack your Prom attire!

Purchase a Luminaria in honor of an OsteoWarrior or OsteoAngel. They will light our way to dinner on Friday evening.

Register for FACTOR

General Session Agenda

Wellness Track Agenda

Shop the Warrior HQ Wishlist

Shop the Warrior HQ Wishlist

Spotlight on Warrior HQ at FACTOR

Warrior HQ is always a magical place at FACTOR. It is where our Junior Advisory Board, OsteoWarriors, and siblings of OsteoWarriors and OsteoAngels connect and find community with others who share similar experiences and a common bond. It is the heart of FACTOR and we are honored to have two incredible Lead Agents planning and managing Warrior HQ this year. Meet Maeve and Michelle! Maeve Smart is an OsteoWarrior and a Senior Clinical Research Coordinator in the Janeway Lab at Dana-Farber Cancer Institute and Michelle Preston is an Advanced Child Life Specialist in the Cancer Center at Children's Hospital of Philadelphia (CHOP).‍

Learn More

Career Connections

- Pediatric Oncology Solid Tumor Clinician Educator

- Clinical Assistant Professor of Pediatrics (Clinician Educator) Hematology-Oncology-CHLA

- Scientist, Osteosarcoma Cell Therapy Initiative, UCSF Roybal Lab, Allen Lab

- Director of the CSU Flint Animal Cancer Center ‍

- Senior Director, Business Development and Strategy - Count Me In/Broad Institute

If you have a job posting and you would like it included here, please email christina@mibagents.org.

^‍

^EDUCATION^‍^‍

^{OsteoBites Webinar Series}

July 25 | Bhuvana Setty, MD
‍A Multi-Institution Study of TGFβ Imprinted, Ex Vivo Expanded Universal Donor NK Cell Infusions as Adoptive Immunotherapy in Combination with Gemcitabine and Docetaxel in Patients with Relapsed or Refractory Pediatric Bone and Soft Tissue (TINKS)

‍

Watch Past Episodes and See the Upcoming Schedule

^{Tumor Review Board for Osteosarcoma}

A virtual tumor review board for osteosarcoma, TURBO is open to global clinicians or researchers with an interest in osteosarcoma. Patients and families are welcome to ask their oncologists to present a case on their behalf. Join TURBO to request an invite or submit a case.

Next meeting: July 10th at 5pm ET

‍Join TURBO

Osteosarcoma in the News

- The unfulfilled promise from a forgotten child

- MIB Agents Junior Advisory Board member MacKenzie Maddry in People magazine

- Payload-delivering engineered γδ T cells display enhanced cytotoxicity, persistence, and efficacy in preclinical models of osteosarcoma

- Targeting nerve growth factor-mediated osteosarcoma metastasis: mechanistic insights and therapeutic opportunities using larotrectinib

- A new way to fight an aggressive cancer in dogs

- Zentalis Pharmaceuticals to Present Promising Results from Phase 1 Trial of Azenosertib and Gemcitabine in Relapsed or Refractory Osteosarcoma at 2024 ASCO Meeting

- Targeting the mitochondrial protein YME1L to inhibit osteosarcoma cell growth in vitro and in vivo

- Single-cell and spatial transcriptomics reveal metastasis mechanism and microenvironment remodeling of lymph node in osteosarcoma

- CT-derived Radiomics Predicts the Efficacy of Tyrosine Kinase Inhibitors in Osteosarcoma Patients with Pulmonary Metastasis

- Trends in primary malignant bone cancer incidence and mortality in the United States, 2000–2017: A population-based study

- Guideline-Concordant Care Is Associated With Reduced Risk of Death in Metastatic Osteosarcoma

- Importance of CD8 Tex cell-associated gene signatures in the prognosis and immunology of osteosarcoma

- Joint-Sparing Resection around the Knee for Osteosarcoma: Long-Term Outcomes of Biologic Reconstruction with Vascularized Fibula Graft Combined with Massive Allograft

PROGRAMS

Get ready for Postcard Month via Warrior Mail!

The July issue of Warrior Mail will be our annual Postcard Month! As you travel this month, please keep your eyes out for postcards for our OsteoWarriors, who all LOVE receiving their “Special Delivery” at the end of July! If you are not yet a Writer Agent, please sign up! The July Warrior Intel will be shared with our Writer Agents on July 7th.

Please email isabel@mibagents.org with any questions.

Learn More

Become a Writer Agent